Phenotypes Associated with This Genotype

Genotype
MGI:2175124

• Allelic Composition: Myf5^tm1Jae/Myf5^tm1Jae
• Genetic Background: either: 129-Myf5^tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:3013 )

• die immediately after birth

respiratory system

respiratory failure ( J:3013 )

• unable to breathe

skeleton

abnormal sternocostal joint morphology ( J:3013 )

• ribs do not attach to the sternum due to their truncation

abnormal sternum ossification ( J:3013 )

• the sternum is completely ossified without sternebral segmentation

short sternum ( J:3013 )

short ribs ( J:3013 )

• absence of the major distal part of the ribs; the cranial rib stumps on both sides of the vertebral column end in dilated enlarged structures

embryo

abnormal somite development ( J:3013 )

• appearance of myotomal cells in early somites is delayed by several days

muscle

abnormal muscle morphology ( J:3013 )

• organization of muscles in the anterior thoracic wall is disorganized, probably due to lack of ribs

abnormal myotome development ( J:3013 )

• muscle-specific marker analysis indicates a delay in the development of the myotome