Phenotypes Associated with This Genotype

Genotype
MGI:2175078

• Allelic Composition: Igf1^tm1Arge/Igf1^tm1Arge
• Genetic Background: either: 129S/SvEv-Igf1^tm1Arge or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:15108 )

• Background Sensitivity: moderate to severe, strain dependent: 10% of129S6/SvEvTac congenic homozygous animals and 16% of (129S6/SvEvTac x C57BL/6J)F2 homozygous animals survive to adulthood while 68% of (129S6/SvEvTac x MF1) homozygous animals survive to adulthood

• death usually occurs between 15 min and 6 hours after birth

growth/size/body

decreased body size ( J:15108 )

• about 25% of recovered neonates exhibit a birthweight approximately 60% of normal

postnatal growth retardation ( J:15108 )

skeleton

delayed bone ossification ( J:15108 )

• ossification is only slightly delayed and does not differ from that of Igf2^tm1Rob mutants