Phenotypes Associated with This Genotype

Genotype
MGI:2175049

• Allelic Composition: Grin1^tm1Stl/Grin1^tm1Stl
• Genetic Background: either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:17384 )

• about 10-20 hours after birth, pups are either thrown out of the nest unattened or are dead inside the nest

behavior/neurological

abnormal suckling behavior ( J:17384 )

• do not have milk in stomachs indicating impaired suckling reflexes

ataxia ( J:17384 )

• severely ataxic and cannot support body weight on their hindlimbs

homeostasis/metabolism

cyanosis ( J:17384 )

• cyanosis appeared shortly before death

respiratory system

apnea ( J:17384 )

• observed increased apnea within several hours of birth

nervous system

abnormal brainstem morphology ( J:17384 )

• absence of barrelettes in the brainstem trigeminal complex

absence of NMDA-mediated synaptic currents ( J:17384 )

• absent slow NMDA receptor-mediated (sensitive to AP5) postsynaptic currents