Phenotypes Associated with This Genotype

Genotype
MGI:2175047

• Allelic Composition: Grin1^tm1Cur/Grin1^tm1Cur
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:66345 )

• 8-15 hours after birth

respiratory system

lung hemorrhage ( J:66345 )

atelectasis ( J:66345 )

overexpanded pulmonary alveolus ( J:66345 )

homeostasis/metabolism

cyanosis ( J:66345 )

• at the time of death, mice have a gray-blue pallor suggestive of respiratory distress

cardiovascular system

cardiovascular system phenotype ( J:66345 )

N • no overt signs of heart defects, cardiac infarction or ventricular enlargement, although signs of vascular congestion is noted

lung hemorrhage ( J:66345 )

behavior/neurological

absent gastric milk in neonates ( J:66345 )

nervous system

nervous system phenotype ( J:66345 )

N • no obvious defects are present in the neuroarchitecture of the CNS, including brain stem regions that are implicated in regulating respiration, swallowing and in cardiac function

abnormal glutamate-mediated receptor currents ( J:66345 )

• cultured granule neuron cells from mutant mice show a depressed response to glutamate at low concentrations

absence of NMDA-mediated synaptic currents ( J:66345 )

• cultured granule neuron cells and hippocampal neurons from mutant mice do not respond to NMDA; intracellular calcium and membrane currents are abolished