Phenotypes Associated with This Genotype

Genotype
MGI:2175041

• Allelic Composition: Gfra1^tm1Jmi/Gfra1⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

intestinal hypoperistalsis ( J:82456 )

• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation

nervous system

abnormal enteric neuron morphology ( J:82456 )

• neuronal cell size is reduced by 19% in colon submucosal neurons, by 20% in colonic myenteric neurons and by 31% in small bowel myenteric neurons, however the number of myenteric and submucosal neurons in the small bowel and colon are normal

• myenteric neuron acetylcholinesterase-stained fiber counts are reduced by 11% in the small bowel and by 12% in the colon

abnormal neurotransmitter secretion ( J:82456 )

• 70-95% reduction in substance P and VIP release

integument

accelerated hair follicle regression ( J:65034 )

• exhibit accelerated catagen development, with a significant decline in the percentage of catagen II hair follicles and an increase of catagen V-VI hair follicles at P17

thin skin ( J:65034 )

• seen at P17

muscle

intestinal hypoperistalsis ( J:82456 )

• decrease in both longitudinal and circular muscle contraction of the intestine in response to electric field stimulation