Phenotypes Associated with This Genotype

Genotype
MGI:2175038

• Allelic Composition: Gdf9^tm1Zuk/Gdf9^tm1Zuk
• Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal ovary morphology ( J:35782 )

♀ • asymmetrical granulosa cell layer

♀ • absent thecal layer

absent corpus luteum ( J:35782 )

♀

abnormal ovarian folliculogenesis ( J:35782 )

♀ • abnormal ovarian folliculogenesis seen beyond the one layer follicle stage

absent mature ovarian follicles ( J:35782 )

♀

small ovary ( J:35782 )

♀ • decreased ovary size visible as early as one week of age

ovary cyst ( J:35782 )

♀ • observed in ages 25-31 weeks

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:35782 )

• increased 3-fold

increased circulating luteinizing hormone level ( J:35782 )

• increased 2-fold

reproductive system

abnormal oogenesis ( J:35782 )

♀

abnormal ovary morphology ( J:35782 )

♀ • asymmetrical granulosa cell layer

♀ • absent thecal layer

absent corpus luteum ( J:35782 )

♀

abnormal ovarian folliculogenesis ( J:35782 )

♀ • abnormal ovarian folliculogenesis seen beyond the one layer follicle stage

absent mature ovarian follicles ( J:35782 )

♀

small ovary ( J:35782 )

♀ • decreased ovary size visible as early as one week of age

ovary cyst ( J:35782 )

♀ • observed in ages 25-31 weeks

female infertility ( J:35782 )

♀ • females, but not males, are infertile

growth/size/body

ovary cyst ( J:35782 )

♀ • observed in ages 25-31 weeks

cellular

abnormal oogenesis ( J:35782 )

♀