Mouse Genome Informatics
hm
    Gabrb3tm1Geh/Gabrb3tm1Geh
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• frequently seen sleeping away from nesting material
• increased time until first contact with a novel object compared to wild-type
• decreased amount of time spent investigating a novel object compared to wild-type
• total number of rearings differs from wild-type littermates and C57BL/6J mice but not from 129X1/SvJ mice
• the mean duration of each rearing event is decreased compared to controls
• a higher degree of ambulatory activity than control mice
• a higher number of entries, in regards to the total transitions between all chambers, of a social interaction apparatus
• fail to show a significant preference for spending time in the interaction chamber adjacent to the stimulus cage containing an unfamiliar mouse as opposed to spending time in the interaction chamber adjacent to an empty stimulus cage
• mice fail to exhibit a preference for interacting with a new mouse over a familiar mouse
• at 1, 24 and 48 hours after introduction of new nestlet material, mice utilize significantly less material than wild-type controls
• significant impairment in their ability to achieve the nest complexity exhibited by the controls
• location of nest construction is different

nervous system
• significant decrease in the surface area
• significant decrease in the surface area
• significant decrease in the surface area
• significant decrease in the surface area
• significant decrease in the surface area
• significant decrease in the surface area

Mouse Models of Human Disease
OMIM IDRef(s)
Autism 209850 J:130259