Analysis Tools
immune system
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• thymocytes are impaired in a late stage of maturation and show limited clonal deletion to the Mls-1a self-superantigen but not to staphylococcal enterotoxin A
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• thymocytes and mature T cells fail to flux calcium to any large extent in response to TCR cross-linking
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• IgG2a is consistently elevated by 30-40%
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• consistently elevated by 30-40%
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• mature T cells fail to flux calcium to any large extent in response to TCR cross-linking
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• thymocytes of each single positive phenotype fail to proliferate in response to anti-CD3 and PMA, in contrast with single positive wild-type thymocytes
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• proliferation of thymocytes in response to anti-CD3 or anti-Thy-1 cross-linking is substantially compromised, however peripheral T cell activation responses are largely functional
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• production of IL-2 by splenic T cells is reduced in response to TCR activation
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behavior/neurological
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• show impaired spatial learning in Morris water maze test
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nervous system
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• exhibit an increased number of granule cells in the dentate gyrus
• exhibit undulation of the granule cell layer
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• undulation of the pyramidal cell layer in the CA3 region and in the dentate gyrus
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• apical dendrites of CA1 pyramidal neurons appear less tightly organized
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• exhibit an increased number of pyramidal cells in the CA3 region
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• LTP is blunted in the CA1 neurons of hippocampal slices, in both the field EPSP and in the population spike, even though synaptic transmission and two short-term forms of synaptic plasticity, paired-pulse facilitation and post-tetanic
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hematopoietic system
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• thymocytes are impaired in a late stage of maturation and show limited clonal deletion to the Mls-1a self-superantigen but not to staphylococcal enterotoxin A
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• IgG2a is consistently elevated by 30-40%
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• consistently elevated by 30-40%
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• mature T cells fail to flux calcium to any large extent in response to TCR cross-linking
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• thymocytes of each single positive phenotype fail to proliferate in response to anti-CD3 and PMA, in contrast with single positive wild-type thymocytes
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• proliferation of thymocytes in response to anti-CD3 or anti-Thy-1 cross-linking is substantially compromised, however peripheral T cell activation responses are largely functional
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endocrine/exocrine glands
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• proliferation of thymocytes in response to anti-CD3 or anti-Thy-1 cross-linking is substantially compromised, however peripheral T cell activation responses are largely functional
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cellular
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• thymocytes of each single positive phenotype fail to proliferate in response to anti-CD3 and PMA, in contrast with single positive wild-type thymocytes
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