Mouse Genome Informatics
hm
    Foxn1nu-Y/Foxn1nu-Y
101/HY-Foxn1nu-Y
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• homozygotes represent about 10.6% of pups from matings of heterozygotes

growth/size/body
• about half normal at 3 weeks of age

immune system
• two rudimentary lobules of thymus in apical mediastinum lack a developed stroma and lymphoid infiltration
• almost completely replaced with adipose and mucoid cells by 7.5 weeks of age
• at 11 days (J:4060)
• absence of mature T-cells although precursors present in bone marrow

hematopoietic system
• two rudimentary lobules of thymus in apical mediastinum lack a developed stroma and lymphoid infiltration
• almost completely replaced with adipose and mucoid cells by 7.5 weeks of age
• at 11 days (J:4060)
• absence of mature T-cells although precursors present in bone marrow

integument

endocrine/exocrine glands
• two rudimentary lobules of thymus in apical mediastinum lack a developed stroma and lymphoid infiltration
• almost completely replaced with adipose and mucoid cells by 7.5 weeks of age
• at 11 days (J:4060)

Mouse Models of Human Disease
OMIM IDRef(s)
T-Cell Immunodeficiency, Congenital Alopecia, and Nail Dystrophy 601705 J:29022