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Phenotypes Associated with This Genotype
Genotype
MGI:2175029
Allelic
Composition
Foxn1nu-Y/Foxn1nu-Y
Genetic
Background
101/HY-Foxn1nu-Y
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu-Y mutation (0 available); any Foxn1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes represent about 10.6% of pups from matings of heterozygotes

growth/size/body
• about half normal at 3 weeks of age

immune system
• two rudimentary lobules of thymus in apical mediastinum lack a developed stroma and lymphoid infiltration
• almost completely replaced with adipose and mucoid cells by 7.5 weeks of age
• at 11 days (J:4060)
• absence of mature T-cells although precursors present in bone marrow

hematopoietic system
• two rudimentary lobules of thymus in apical mediastinum lack a developed stroma and lymphoid infiltration
• almost completely replaced with adipose and mucoid cells by 7.5 weeks of age
• at 11 days (J:4060)
• absence of mature T-cells although precursors present in bone marrow

integument

endocrine/exocrine glands
• two rudimentary lobules of thymus in apical mediastinum lack a developed stroma and lymphoid infiltration
• almost completely replaced with adipose and mucoid cells by 7.5 weeks of age
• at 11 days (J:4060)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory