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Phenotypes Associated with This Genotype
Genotype
MGI:2175018
Allelic
Composition		 Tnftm1Ljo/Tnf+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm1Ljo mutation (3 available); any Tnf mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:41992 )
• exhibit increased susceptibility to high-dose LPS lethality
• exhibit delayed resolution of the Corynebacterium parvum induced inflammatory process lipopolysaccharide (LPS) lethality
increased susceptibility to fungal infection ( J:41992 )
• exhibit increased susceptibility to Candida albicans challenge; 60% die by 30 days post-infection

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory