Mouse Genome Informatics
hm
    Ptger4tm1Bhk/Ptger4tm1Bhk
involves: 129P2/OlaHsd * 129S/SvEv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• homozygotes obtained from crosses with 129S/SvEv mice are alive at 12 hours after birth; however, most of them die within 48 hours after birth
• no homozygotes survive to weaning
• Background Sensitivity: selective breeding of the 5% of homozygotes that survive on a mixed genetic (129P2/OlaHsd x C57BL/6 x DBA/2) background results in a 21% survival rate

cardiovascular system
• mutant lungs display congestion of pulmonary septal capillaries
• in a number of homozygotes that die at >24 h after birth, mutant livers display changes compatible with passive congestion
• such changes are suggestive of acute ischemia secondary to heart failure
• mutant lungs exhibit congestion of pulmonary septal capillaries
• although the DA appears constricted relative to the fetal DA at 3 hrs after birth, homozygous newborns exhibit obvious patency of the DA at both 7 and 12 hrs after birth
• at 12 hrs, swelling of the intima absent and the endothelium remains a single layer of cells contiguous with that of the aorta
• mutant lungs display a left-to-right shunt of blood
• homozygotes exhibit hemorrhaging into the alveolar spaces and major respiratory ducts
• homozygotes show a postnatal drop in pulmonary vascular resistance

respiratory system
• mutant lungs display a left-to-right shunt of blood
• homozygotes exhibit hemorrhaging into the alveolar spaces and major respiratory ducts
• mutant lungs exhibit congestion of pulmonary septal capillaries
• homozygotes exhibit a higher lung-to-body-weight ratio relative to wild-type mice

immune system
• homozygotes display dilated perivascular lymphatics

liver/biliary system
• in a number of homozygotes that die at >24 h after birth, mutant livers display changes compatible with passive congestion
• such changes are suggestive of acute ischemia secondary to heart failure
• in a number of homozygotes dying at >24 h after birth, mutant livers contain macro- and microvesicular lipid deposits

homeostasis/metabolism

Mouse Models of Human Disease
OMIM IDRef(s)
Patent Ductus Arteriosus 607411 J:44108