Phenotypes Associated with This Genotype

Genotype
MGI:2175004

• Allelic Composition: Ptger1^tm1Sna/Ptger1^tm1Sna
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:70534 )

N • homozygotes are fertile, grow normally, live longer than 1 year and display no overt morphological abnormalities

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:70534 )

N • homozygotes exhibit a normal febrile response to PGE2 and to either IL-1-beta or LPS relative to wild-type mice

abnormal physiological response to xenobiotic ( J:103150 )

• the gastric hyperaemic response to taurocholate is blocked

• the time to recovery of baseline gastric potential difference after exposure to taurocholate is increased

• however, the decrease in potential difference induced by taurocholate is similar to controls

increased physiological sensitivity to xenobiotic ( J:103150 )

• treatment with taurocholate plus acid induces severe lesions in the gastric mucosa with a lesion score 3.2 times higher than in wild-type littermate controls