Mouse Genome Informatics
hm
    Irs1tm1Tka/Irs1tm1Tka
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
growth/size
• at 3, 8, and 15 weeks, the weights of homozygotes are ~30% less than those of wild-type or heterozygous littermates
• homozygotes are viable and fertile but exhibit a growth retardation at 3, 8, and 15 weeks of age
• at E18.5, the weights of homozygotes are ~80% of those of wild-type or heterozygous controls
• at E15.5, homozygotes display growth retardation relative to wild-type controls

homeostasis/metabolism
N
• homozygotes display normal serum IGF1, IGF2 and growth hormone levels relative to wild-type mice (J:21373)
• homozygotes maintain normal fasting glucose and glucose tolerance (by compensatory beta-cell hyperplasia)
• homozygotes exhibit a higher basal glucose transport of adipocytes relative to wild-type mice; in contrast, insulin-stimulated glucose transport of mutant adipocytes is significantly impaired
• the serum insulin levels of homozygotes before and after glucose load are significantly higher than those of wild-type and heterozygous mutant mice
• homozygotes exhibit a mild to moderate insulin, IGF1, and IGF2 resistance

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:21373