Mouse Genome Informatics
hm
    Insrtm1Jja/Insrtm1Jja
involves: 129S2/SvPas * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mice die within one week of birth

growth/size
• reduction in adipose tissue
• homozygous animals weighed 30 - 40% less than controls

homeostasis/metabolism
• plasma triglyceride levels were 6 fold higher than controls
• liver glycogen content could decrease 5 fold compared to controls
• plasma fatty acid concentrations visibly elevated
• homozygous mice developed diabetic ketoacidosis, with glucose and ketone bodies in urine (J:32538)

liver/biliary system
• fatty infiltration of the liver was noted (J:32538)

muscle
• marked hypotrophy, apparent in days following birth

renal/urinary system
• homozygous mice developed diabetic ketoacidosis, with glucose and ketone bodies in urine (J:32538)

adipose tissue
• reduction in adipose tissue

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Donohue Syndrome 246200 J:32538
NOT Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, and Somatic Abnormalities 262190 J:32538