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Phenotypes Associated with This Genotype
Genotype
MGI:2174961
Allelic
Composition
Insrtm1Jja/Insrtm1Jja
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Jja mutation (0 available); any Insr mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within one week of birth (J:32538)
• mice die within one week of birth (J:32538)

growth/size/body
• reduction in adipose tissue (J:80773)
• reduction in adipose tissue (J:80773)
• homozygous animals weighed 30 - 40% less than controls (J:32538)
• homozygous animals weighed 30 - 40% less than controls (J:32538)

homeostasis/metabolism
• plasma triglyceride levels were 6 fold higher than controls (J:32538)
• plasma triglyceride levels were 6 fold higher than controls (J:32538)
• liver glycogen content could decrease 5 fold compared to controls (J:32538)
• liver glycogen content could decrease 5 fold compared to controls (J:32538)
• plasma fatty acid concentrations visibly elevated (J:32538)
• plasma fatty acid concentrations visibly elevated (J:32538)
• homozygous mice developed diabetic ketoacidosis, with glucose and ketone bodies in urine (J:32538)
• homozygous mice developed diabetic ketoacidosis, with glucose and ketone bodies in urine (J:32538)

liver/biliary system
• fatty infiltration of the liver was noted (J:32538)
• fatty infiltration of the liver was noted (J:32538)

muscle
• marked hypotrophy, apparent in days following birth (J:32538)
• marked hypotrophy, apparent in days following birth (J:32538)

renal/urinary system
• homozygous mice developed diabetic ketoacidosis, with glucose and ketone bodies in urine (J:32538)
• homozygous mice developed diabetic ketoacidosis, with glucose and ketone bodies in urine (J:32538)

adipose tissue
• reduction in adipose tissue (J:80773)
• reduction in adipose tissue (J:80773)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory