Mouse Genome Informatics
hm
    Insrtm1Dac/Insrtm1Dac
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• mice die within 72 hours of birth

homeostasis/metabolism
• about 10% with diabetes
• plasma glucose levels rose sharply after birth; measured between 24-37 mmol/l
• plasma insulin levels rose sharply after birth to levels approximately 7 times that of controls
• homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine; urinary acetoacetate measured between 8-16 mmol/l

liver/biliary system
• steatosis; fatty degeneration of liver

renal/urinary system
• homozygous mice developed diabetic ketoacidosis, with ketone bodies in urine; urinary acetoacetate measured between 8-16 mmol/l

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Donohue Syndrome 246200 J:33408