Phenotypes for Cdk4 MGI:2174939 MGI Mouse

mortality/aging

• 22% of homozygous mutant mice died by 28 days after birth

growth/size/body

decreased body size ( J:57854 )

• at birth, homozygous mutant mice were 20% smaller than wild-type or heterozygous littermates

• adult homozygous mutant mice were approximately 42% smaller than wild-type or heterozygous littermates

reproductive system

oligozoospermia ( J:57854 )

• reduced numbers of spermatogonia/spermatocytes

abnormal corpus luteum morphology ( J:57854 )

• perturbation of organization of granulosa/luteal cells

abnormal testis morphology ( J:57854 )

• testicular dysplasia

small seminiferous tubules ( J:57854 )

• reduced diameter of seminiferous epithelial tubules

small testis ( J:57854 )

impaired luteinization ( J:57854 )

• aberrant luteinization, with oocytes trapped

abnormal fertility/fecundity ( J:57854 )

female infertility ( J:57854 )

• all females infertile

reduced male fertility ( J:57854 )

• only 10% of males fertile

homeostasis/metabolism

increased urine glucose level ( J:57854 )

• by 6 to 7 weeks, 60 - 80% of homozygous mutant mice started exhibiting glucosuria; remaining mice showed no such phenotype up to 40 weeks

endocrine/exocrine glands

• degeneration of endocrine islet cells

• at 3 weeks of age, pancreas had fewer islets, many of which had disorganized cellularity and dying cells with condensed nuclei