Phenotypes Associated with This Genotype

Genotype
MGI:2174935

• Allelic Composition: Aqp4^tm1Ask/Aqp4^tm1Ask
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

decreased urine osmolality ( J:42704 , J:46296 )

• urine osmolality is similar to wild-type when water is freely available but maximum urine osmolality is reduced following 36 hours of water deprivation (J:42704)

• however, kidney morphology is similar to wild-type (J:42704)

• after 36 hour water deprivation or intraperitoneal injection of desmopressin (J:46296)

abnormal renal water transport ( J:46296 )

• osmotic water permeability of inner medullary collecting ducts is decreased to 13.1 +/- 3.7 cm/s x 10^-3 compared to 56.0 +/- 8.5 cm/s x 10^-3 in wild-type mice

vision/eye

abnormal eye electrophysiology ( J:74263 )

• at 10 months of age b-wave amplitudes and latencies are reduced; however, no differences in retinal morphology are detected

homeostasis/metabolism

decreased urine osmolality ( J:42704 , J:46296 )

• urine osmolality is similar to wild-type when water is freely available but maximum urine osmolality is reduced following 36 hours of water deprivation (J:42704)

• however, kidney morphology is similar to wild-type (J:42704)

• after 36 hour water deprivation or intraperitoneal injection of desmopressin (J:46296)

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:56302 )

N • homozygotes display no defects in the volume or composition of saliva, as revealed by pilocarpine stimulation studies