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Phenotypes Associated with This Genotype
Genotype
MGI:2174929
Allelic
Composition
Apoetm1Lmh/Apoetm1Lmh
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Lmh mutation (0 available); any Apoe mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 2-fold increase in serum cholesterol when fed normal chow
• 3-fold increase in serum cholesterol when fed a hypercholesterolemic diet
• no increase in HDL
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet
• 160-fold increase in serum VLDL + LDL when fed normal chow
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet
• 160-fold increase in serum VLDL + LDL when fed normal chow
• when fed a hypercholesterolemic diet for 14 weeks prior to sacrifice, 6 - 7 month old mice showed increased incidence of xanthomatous lesions in multiple tissues, including skin, salivary glands, thyroid glands, muscles, periosteum and upper mediastinum, including the thymus, mesothelium of bladder and kidney, nasal mucosa, choroids plexus, third ventricle, and meniges of the brain and the meniges of spinal cord

Mouse Models of Human Disease
OMIM ID Ref(s)
Apolipoprotein E; APOE 107741 J:22347
NOT Sea-Blue Histiocyte Disease 269600 J:22347


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory