Phenotypes Associated with This Genotype

Genotype
MGI:2174929

• Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:22347 )

increased circulating cholesterol level ( J:22347 )

• 2-fold increase in serum cholesterol when fed normal chow

• 3-fold increase in serum cholesterol when fed a hypercholesterolemic diet

• no increase in HDL

increased circulating HDL cholesterol level ( J:22347 )

• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet

• 160-fold increase in serum VLDL + LDL when fed normal chow

increased circulating VLDL cholesterol level ( J:22347 )

• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet

• 160-fold increase in serum VLDL + LDL when fed normal chow

xanthoma ( J:24054 )

• when fed a hypercholesterolemic diet for 14 weeks prior to sacrifice, 6 - 7 month old mice showed increased incidence of xanthomatous lesions in multiple tissues, including skin, salivary glands, thyroid glands, muscles, periosteum and upper mediastinum, including the thymus, mesothelium of bladder and kidney, nasal mucosa, choroids plexus, third ventricle, and meniges of the brain and the meniges of spinal cord