Mouse Genome Informatics
hm
    Apoetm1Lmh/Apoetm1Lmh
involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• 2-fold increase in serum cholesterol when fed normal chow
• 3-fold increase in serum cholesterol when fed a hypercholesterolemic diet
• no increase in HDL
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet
• 160-fold increase in serum VLDL + LDL when fed normal chow
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet
• 160-fold increase in serum VLDL + LDL when fed normal chow
• when fed a hypercholesterolemic diet for 14 weeks prior to sacrifice, 6 - 7 month old mice showed increased incidence of xanthomatous lesions in multiple tissues, including skin, salivary glands, thyroid glands, muscles, periosteum and upper mediastinum, including the thymus, mesothelium of bladder and kidney, nasal mucosa, choroids plexus, third ventricle, and meniges of the brain and the meniges of spinal cord

Mouse Models of Human Disease
OMIM IDRef(s)
Apolipoprotein E; APOE 107741 J:22347
NOT Sea-Blue Histiocyte Disease 269600 J:22347