About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2174917
Allelic
Composition
Apptm1Dbo/Apptm1Dbo
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Dbo mutation (1 available); any App mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• age-related impairment in conditioned avoidance tests, seen at 10 months of age, but not at 4 months of age (J:53824)
• age-related impairment in conditioned avoidance tests, seen at 10 months of age, but not at 4 months of age (J:53824)
• impairment in watermaze test of spatial learning, both at 4 and 10 months of age (J:53824)
• impairment in watermaze test of spatial learning, both at 4 and 10 months of age (J:53824)
• significantly reduced grip strength (J:25512)
• significantly reduced grip strength (J:25512)
• decreased locomotor activity (J:25512)
• decreased locomotor activity (J:25512)

nervous system
• reactive gliosis was observed throughout the cortical layers of the neocortex and extensive astrogliosis was seen in the CA1 region of the hippocampus, however did not observe neuronal cell damage (J:25512)
• reactive gliosis was observed throughout the cortical layers of the neocortex and extensive astrogliosis was seen in the CA1 region of the hippocampus, however did not observe neuronal cell damage (J:25512)
• reactive astrocytosis in many brain areas, but predominantly in the cortex and hippocampus at 14 weeks of age (J:53824)
• reactive astrocytosis in many brain areas, but predominantly in the cortex and hippocampus at 14 weeks of age (J:53824)
• the branching of dendrites of both cortical and hippocampal neurons was much less extensive, however did not show any loss of cells in the cortex or the hippocampus (J:53824)
• the branching of dendrites of both cortical and hippocampal neurons was much less extensive, however did not show any loss of cells in the cortex or the hippocampus (J:53824)
• impairment of ability of high frequency stimuli to induce LTP which correlated with extent of gliosis in stratum radiatum (J:53824)
• impairment of ability of high frequency stimuli to induce LTP which correlated with extent of gliosis in stratum radiatum (J:53824)

growth/size/body
• body weight was 15-20% less at all ages compared with that of controls (J:25512)
• body weight was 15-20% less at all ages compared with that of controls (J:25512)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:53824


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory