Mouse Genome Informatics
involves: 129S7/SvEvBrd * C57BL/6J
phenotype observed in females
phenotype observed in males
N normal phenotype
• age-related impairment in conditioned avoidance tests, seen at 10 months of age, but not at 4 months of age
• impairment in watermaze test of spatial learning, both at 4 and 10 months of age
• significantly reduced grip strength
• decreased locomotor activity

nervous system
• reactive gliosis was observed throughout the cortical layers of the neocortex and extensive astrogliosis was seen in the CA1 region of the hippocampus, however did not observe neuronal cell damage
• reactive astrocytosis in many brain areas, but predominantly in the cortex and hippocampus at 14 weeks of age
• the branching of dendrites of both cortical and hippocampal neurons was much less extensive, however did not show any loss of cells in the cortex or the hippocampus
• impairment of ability of high frequency stimuli to induce LTP which correlated with extent of gliosis in stratum radiatum

• body weight was 15-20% less at all ages compared with that of controls

Mouse Models of Human Disease
Alzheimer Disease; AD 104300 J:53824