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Phenotypes Associated with This Genotype
Genotype
MGI:2174908
Allelic
Composition
Ppp3catm1Jse/Ppp3catm1Jse
Genetic
Background
either: (involves: 129S4/SvJae * Black Swiss) or (involves: 129S4/SvJae * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3catm1Jse mutation (1 available); any Ppp3ca mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• T cell proliferation in response to ovalbumin stimulation is lower than for wild-type mice and is not complimented by normal antibody producing cells or IL-2
• T cells proliferation is more sensitive to cyclosporine A and FK506 exhibiting a 2- to 7-fold lower decreased in proliferation compared to wild-type mice
• when stimulated with ovalbumin, mice produce less interferon-gamma than wild-type mice
• when stimulated with ovalbumin, mice produce less IL-2 than wild-type mice
• however, primary antibody response is normal in response to TNP-ovalbumin
• when stimulated with ovalbumin, mice produce less IL-4 than wild-type mice

hematopoietic system
• T cell proliferation in response to ovalbumin stimulation is lower than for wild-type mice and is not complimented by normal antibody producing cells or IL-2
• T cells proliferation is more sensitive to cyclosporine A and FK506 exhibiting a 2- to 7-fold lower decreased in proliferation compared to wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory