Phenotypes Associated with This Genotype

Genotype
MGI:2174908

• Allelic Composition: Ppp3ca^tm1Jse/Ppp3ca^tm1Jse
• Genetic Background: either: (involves: 129S4/SvJae * Black Swiss) or (involves: 129S4/SvJae * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:71750 )

• T cell proliferation in response to ovalbumin stimulation is lower than for wild-type mice and is not complimented by normal antibody producing cells or IL-2

• T cells proliferation is more sensitive to cyclosporine A and FK506 exhibiting a 2- to 7-fold lower decreased in proliferation compared to wild-type mice

decreased interferon-gamma secretion ( J:71750 )

• when stimulated with ovalbumin, mice produce less interferon-gamma than wild-type mice

decreased interleukin-2 secretion ( J:71750 )

• when stimulated with ovalbumin, mice produce less IL-2 than wild-type mice

• however, primary antibody response is normal in response to TNP-ovalbumin

decreased interleukin-4 secretion ( J:71750 )

• when stimulated with ovalbumin, mice produce less IL-4 than wild-type mice

hematopoietic system

decreased T cell proliferation ( J:71750 )

• T cell proliferation in response to ovalbumin stimulation is lower than for wild-type mice and is not complimented by normal antibody producing cells or IL-2

• T cells proliferation is more sensitive to cyclosporine A and FK506 exhibiting a 2- to 7-fold lower decreased in proliferation compared to wild-type mice

cellular

decreased T cell proliferation ( J:71750 )

• T cell proliferation in response to ovalbumin stimulation is lower than for wild-type mice and is not complimented by normal antibody producing cells or IL-2

• T cells proliferation is more sensitive to cyclosporine A and FK506 exhibiting a 2- to 7-fold lower decreased in proliferation compared to wild-type mice