Phenotypes for Six5 MGI:2174897 MGI Mouse

nuclear cataract ( J:61881 )

• less severe than homozygote

• opacities and lens tissue destruction were apparent in the nucleus of the lens at three weeks of age by both slit-lamp and histological analyses

• increasing incidence and severity with age noted at 8 weeks of age compared to 3 weeks of age; as cataract formation progressed, both the opacities and the region of tissue destruction were observed to spread towards the cortex of the lens

• histological analysis showed no gross morphological alterations in any other areas of the eye

• retinal structure and function are unimpaired

• Background Sensitivity: variable penetrance; more severe on this inbred genetic background than on a mixed genetic background

oligozoospermia ( J:91207 )

• counts of terminally differentiated spermatozoa in the seminal fluid of the heterozygous mice were 60% of the controls

abnormal testis morphology ( J:91207 )

small seminiferous tubules ( J:91207 )

• heterozygous mice show decreased tubule diameter; less severe than homozygote

seminiferous tubule degeneration ( J:91207 )

• apoptotic cells within the seminiferous tubules were observed

• 5-fold increase in apoptotic cell death was observed when compared with the controls

increased circulating follicle stimulating hormone level ( J:91207 )

• at 3 months of age, increased FSH levels in the heterozygous mice were observed when compared with controls