Phenotypes Associated with This Genotype

Genotype
MGI:2174896

• Allelic Composition: Six5^tm1Rdd/Six5^tm1Rdd
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

cataract ( J:61881 )

• opacities and lens tissue destruction were apparent in the nucleus of the lens at three weeks of age by both slit-lamp and histological analyses

• increasing incidence and severity with age noted at 8 weeks of age compared to 3 weeks of age; as cataract formation progressed, both the opacities and the region of tissue destruction were observed to spread towards the cortex of the lens

• histological analysis showed no gross morphological alterations in any other areas of the eye

• retinal structure and function are unimpaired

• Background Sensitivity: variable penetrance; less severe on this mixed genetic background than on an inbred genetic background

• more severe than heterozygote