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Phenotypes Associated with This Genotype
Genotype
MGI:2174870
Allelic
Composition
Tg(Msx2)1Rem/0
Genetic
Background
involves: C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• skulls exhibit a small patch of ectopic bone centered above the posterior portion of the sagittal suture just anterior to the lambdoid suture (J:26513)
• skulls exhibit a small patch of ectopic bone centered above the posterior portion of the sagittal suture just anterior to the lambdoid suture (J:26513)

skeleton
• skulls exhibit a small patch of ectopic bone centered above the posterior portion of the sagittal suture just anterior to the lambdoid suture (J:26513)
• skulls exhibit a small patch of ectopic bone centered above the posterior portion of the sagittal suture just anterior to the lambdoid suture (J:26513)
• premature suture closure of the calvarium (J:26513)
• premature suture closure of the calvarium (J:26513)

hearing/vestibular/ear

vision/eye

integument
• the angle of hair follicles is irregular and thus some hair shafts appear to fail to find a way out (J:56777)
• the angle of hair follicles is irregular and thus some hair shafts appear to fail to find a way out (J:56777)
• increase in the number of empty hair follicles (J:56777)
• increase in the number of empty hair follicles (J:56777)
• bulb regions of the hair follicle are poorly developed and there are fewer matrix epithelial cells (J:56777)
• bulb regions of the hair follicle are poorly developed and there are fewer matrix epithelial cells (J:56777)
• shrunken hair matrixes (J:56777)
• shrunken hair matrixes (J:56777)
• at the proximal level of the follicle, the concentric rings of the matrix cells are lost and replaced by irregularly arranged cells (J:56777)
• at the proximal level of the follicle, the concentric rings of the matrix cells are lost and replaced by irregularly arranged cells (J:56777)
• the inner root sheath region is poorly developed (J:56777)
• the inner root sheath region is poorly developed (J:56777)
• at the proximal level of the follicle, the concentric rings of the inner root sheath are lost and replaced by irregularly arranged cells (J:56777)
• at the proximal level of the follicle, the concentric rings of the inner root sheath are lost and replaced by irregularly arranged cells (J:56777)
• at the proximal level of the follicle, the concentric rings of the outer root sheath are lost and replaced by irregularly arranged cells (J:56777)
• at the proximal level of the follicle, the concentric rings of the outer root sheath are lost and replaced by irregularly arranged cells (J:56777)
• thinner outer root sheath (J:56777)
• thinner outer root sheath (J:56777)
• hair follicles are spread through different depths of the dermal layer (J:56777)
• hair follicles are spread through different depths of the dermal layer (J:56777)
• hair follicles are misaligned and exhibit an irregular angle (J:56777)
• hair follicles are misaligned and exhibit an irregular angle (J:56777)
• skin phenotypes are most severe in the first 2 weeks after birth and gradually decrease such that by 1 month of age, they are no longer apparent (J:56777)
• the occipital, posterior body, and flank regions are most affected (J:56777)
• skin phenotypes are most severe in the first 2 weeks after birth and gradually decrease such that by 1 month of age, they are no longer apparent (J:56777)
• the occipital, posterior body, and flank regions are most affected (J:56777)
• vacuolated tissue and absence of connective tissue (J:56777)
• vacuolated tissue and absence of connective tissue (J:56777)
• increase in cellularity and dysplastic changes in the epidermis, with irregular epidermal invaginations with embedded hair follicles (J:56777)
• increase in cellularity and dysplastic changes in the epidermis, with irregular epidermal invaginations with embedded hair follicles (J:56777)
• cell density in the stratum basale is higher than in wild-type (J:56777)
• cell density in the stratum basale is higher than in wild-type (J:56777)
• the orderly and parallel transition of cells from the stratum spinosum to the corneum is disrupted and instead, many cells are randomly distributed in the suprabasal layers (J:56777)
• the orderly and parallel transition of cells from the stratum spinosum to the corneum is disrupted and instead, many cells are randomly distributed in the suprabasal layers (J:56777)
• thickend suprabasal layer with increased cellularity that is misaligned (J:56777)
• thickend suprabasal layer with increased cellularity that is misaligned (J:56777)

Mouse Models of Human Disease
OMIM ID Ref(s)
Craniosynostosis 2; CRS2 604757 J:26513


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory