Phenotypes Associated with This Genotype

Genotype
MGI:2174823

• Allelic Composition: Tg(BCL2L1)2Cbt/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

increased keratinocyte proliferation ( J:65162 )

• despite a 50% increase in keratinocyte proliferation, the epidermis is normal, indicating increased turnover of keratinocytes

• epidermal terminal differentiation and development and rate of wound repair are normal

increased sensitivity to skin irradiation ( J:65162 )

• increase in the number of apoptotic cells in skin and a marked reduction of keratinocytes in the basal or suprabasal layer 24 hours after UV irradiation

cellular

increased keratinocyte proliferation ( J:65162 )

• despite a 50% increase in keratinocyte proliferation, the epidermis is normal, indicating increased turnover of keratinocytes

• epidermal terminal differentiation and development and rate of wound repair are normal