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Phenotypes Associated with This Genotype
Genotype
MGI:2174818
Allelic
Composition
Tg(APPV717F)109Ili/0
Genetic
Background
Not Specified
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• deposits of human beta-amyloid are seen in the hippocampus, corpus callosum and cerebral cortex, beginning at 6 - 9 months, and increasing in density with age (J:23080)
• mice develop plaques by 12 months of age in the hippocampus and the outer molecular layer of the dentate gyrus with a subset of plaques positive for fibrillar amyloid (J:127846)
• plaque deposition increases with age with greater than 85% of the hippocampus covered in plaques at 24 months of age (J:127846)
• synaptic and dendritic density are reduced in the molecular layer
• amyoid plaques are associated with distorted neurites
• the majority of amyloid plaques are surrounded by GFAP-positive reactive astrocytes

homeostasis/metabolism
• deposits of human beta-amyloid are seen in the hippocampus, corpus callosum and cerebral cortex, beginning at 6 - 9 months, and increasing in density with age (J:23080)
• mice develop plaques by 12 months of age in the hippocampus and the outer molecular layer of the dentate gyrus with a subset of plaques positive for fibrillar amyloid (J:127846)
• plaque deposition increases with age with greater than 85% of the hippocampus covered in plaques at 24 months of age (J:127846)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:23080


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory