Phenotypes Associated with This Genotype

Genotype
MGI:2174779

• Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:1999 , J:126497 )

• 6 of 35 die from unknown causes, with no tumors (J:1999)

• mice succumb to tumorigenesis by 8 months of age (J:126497)

neoplasm

increased tumor incidence ( J:1999 , J:108183 )

• 26 of 35 (76%) develop a variety of neoplasms by 6 months of age (J:1999)

• tumor occurrence increases rapidly between 15 and 25 weeks of age (J:1999)

• spontaneously develop fatal tumors by 10 months of age (J:108183)

increased lymphoma incidence ( J:1999 )

• most frequent tumors observed are malignant lymphomas that involve the thymus and other major visceral organs

increased T cell derived lymphoma incidence ( J:126497 )

• in 18 of 26 mice

increased sarcoma incidence ( J:1999 , J:126497 )

• sarcomas are also frequently observed and include hemangiosarcoma, undifferentiated sarcomas and osteosarcoma (J:1999)

• in 8 of 26 mice (J:126497)

increased hemangiosarcoma incidence ( J:1999 )

increased osteosarcoma incidence ( J:1999 )

cellular

abnormal cell cycle checkpoint function ( J:126497 )

• the G2 to M check point is impaired after irradiation of mouse embryonic fibroblasts

decreased apoptosis ( J:66953 , J:108183 , J:126497 )

• MEFs sensitized to apoptosis by E1A overexpression show very low levels of apoptosis induced by irradiation or chemical treatment compared to wild-type or Trp53^tm1Wahl MEFs (J:108183)

• p53-dependent apoptosis following exposure to radiation is abolished (J:126497)

decreased neuron apoptosis ( J:66953 )

• E12.5 primary telencephalic cultures show resistance to AraC induced caspase 3 activation and neuronal cell death

nervous system

decreased neuron apoptosis ( J:66953 )

• E12.5 primary telencephalic cultures show resistance to AraC induced caspase 3 activation and neuronal cell death

skeleton

increased osteosarcoma incidence ( J:1999 )

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:126497 )

• in 18 of 26 mice