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Phenotypes Associated with This Genotype
Genotype
MGI:2174706
Allelic
Composition
Pkd2tm2Som/Pkd2+
Genetic
Background
involves: 129/Sv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkd2tm2Som mutation (0 available); any Pkd2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

renal/urinary system
• 21% exhibit unilateral renal cysts (J:47035)
• 29% of 62-88 week old heterozygotes have sparse unilateral renal cysts, however none have bilateral cysts or elevated serum urea nitrogen (J:59314)

liver/biliary system
• 10% exhibit liver cysts (J:47035)
• 53% of 62-88 week old heterozygotes have liver cysts (J:59314)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
polycystic kidney disease 2 DOID:0110859 OMIM:613095
J:59314


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory