Phenotypes Associated with This Genotype

Genotype
MGI:2174687

• Allelic Composition: Brca1^tm1Whl/Brca1^tm1Whl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:34458 )

• embryos die prior to E8.5

embryo

abnormal developmental patterning ( J:34458 )

embryonic growth retardation ( J:34458 )

• at E7.5, embryos are severely developmentally retarded

• in cultured blastocysts, impaired outgrowth of the inner cell mass is seen after 5 days in culture

decreased embryo size ( J:34458 )

• at E4.5-E5.5, embryos are at least 50% smaller than controls

abnormal embryonic tissue morphology ( J:34458 )

absent egg cylinders ( J:34458 )

absent mesoderm ( J:34458 )

• at E7.5, no mesoderm formation is apparent

disorganized embryonic tissue ( J:34458 )

• by E6.5, embryos show cellular disorganization and are starting to degenerate

growth/size/body

embryonic growth retardation ( J:34458 )

• at E7.5, embryos are severely developmentally retarded

• in cultured blastocysts, impaired outgrowth of the inner cell mass is seen after 5 days in culture

decreased embryo size ( J:34458 )

• at E4.5-E5.5, embryos are at least 50% smaller than controls

cellular

decreased cell proliferation ( J:34458 )

• in vitro experiments show that the reduced size of mutant embryos is due to a decrease in embryonic cell proliferation and is not due to apoptosis