Phenotypes Associated with This Genotype

Genotype
MGI:2174676

• Allelic Composition: Brca1^tm1Bhk/Brca1^tm1Bhk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:31571 )

• embryos die around E9.5 - E10.5

embryo

decreased embryo size ( J:31571 )

• embryos appear underdeveloped by E8.5 and are clearly smaller at E9.5

abnormal embryonic neuroepithelial layer differentiation ( J:31571 )

• abnormal contours in the neuroepithelium are seen

• excessive cell death is noted in selected cell populations, especially in the hindbrain

open neural tube ( J:31571 )

• fail to close the neural tube completely

spina bifida ( J:31571 )

• variable degrees of severity are observed

nervous system

abnormal embryonic neuroepithelial layer differentiation ( J:31571 )

• abnormal contours in the neuroepithelium are seen

• excessive cell death is noted in selected cell populations, especially in the hindbrain

open neural tube ( J:31571 )

• fail to close the neural tube completely

spina bifida ( J:31571 )

• variable degrees of severity are observed

exencephaly ( J:31571 )

• variable degrees of severity are observed

growth/size/body

decreased embryo size ( J:31571 )

• embryos appear underdeveloped by E8.5 and are clearly smaller at E9.5