Phenotypes Associated with This Genotype

Genotype
MGI:2173313

• Allelic Composition: Nrg1^tm2Cbm/Nrg1^tm2Cbm
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal sympathetic ganglion morphology ( J:48515 )

• lack neural crest cell precursor cells in the anlage of the primary sympathetic ganglion chain

decreased Schwann cell number ( J:43309 )

• reduced number of Schwann cell precursors that line the spinal nerves of the trunk, indicating that type III neuregulin is necessary and sufficient for Schwann cell precursor development

embryo

abnormal neural crest cell migration ( J:48515 )

• severe reduction in the numbers of neural crest cells that migrate to the dorsal aorta

cellular

abnormal neural crest cell migration ( J:48515 )

• severe reduction in the numbers of neural crest cells that migrate to the dorsal aorta