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Phenotypes Associated with This Genotype
Genotype
MGI:2172625
Allelic
Composition
Dnah11iv/Dnah11iv
Genetic
Background
involves: C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnah11iv mutation (4 available); any Dnah11 mutation (136 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• the nodal cilia are rigid and appear frozen
• nodal cilia seldom move and beads added to the extraembryonic fluid fail to display any net directional movement indicating a lack of nodal flow

growth/size/body
• situs inversus with incomplete penetrance and variable expressivity can yield complete situs inversus of thoracic and abdominal viscera and associated blood vessels, incomplete situs inversus, anomalous relationship of the postcaval and azygous veins, anomalous positioning of the hepatic portal vein, flatter more elongated spleen, and diminished or altered lobulation of the liver or lung
• about 50 per cent of homozygotes showed left-right transposition of stomach and abdominal viscera
• about 50% of all the homozygotes showed discordance in asymmetry between the stomach and the major abdominal and thoracic veins, the discordance occurring with similar frequency in mice with normal and reversed viscera
• Background Sensitivity: penetrance is 71%

cellular
• the nodal cilia are rigid and appear frozen
• nodal cilia seldom move and beads added to the extraembryonic fluid fail to display any net directional movement indicating a lack of nodal flow

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
primary ciliary dyskinesia 7 DOID:0110605 OMIM:611884
J:212


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory