Phenotypes Associated with This Genotype

Genotype
MGI:2172508

• Allelic Composition: Ngf^tm1Gne/Ngf^tm1Gne
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:17792 )

• some mutants die within the first 3 days of birth and others are able to ingest some food and survive 1-4 weeks

behavior/neurological

tremors ( J:17792 )

• some mutants surviving the first week develop a tremor, that is most evident during locomotion

abnormal gait ( J:17792 )

• some mutants surviving the first week show mild gait abnormalities

hypoalgesia ( J:17792 )

• unresponsive to tactile stimuli, decrease pain responsiveness in tail flick test, absent pain responsiveness in tail pinch test

growth/size/body

decreased body size ( J:17792 )

• smaller at birth

decreased body weight ( J:17792 )

• weights range from 75-95% of the mean weights of controls mutants fail to gain weight

postnatal growth retardation ( J:17792 )

• homozygotes that survive the first days of life gain weight more slowly and are developmentally delayed

vision/eye

delayed eyelid opening ( J:17792 )

• delayed opening, blepharoptosis (droopy eyelid)

blepharoptosis ( J:17792 )

• all mutants surviving until eye opening display ptosis

nervous system

abnormal sympathetic ganglion morphology ( J:17792 )

absent superior cervical ganglion ( J:17792 )

• by P14, superior cervical ganglia are not visible

• however, the nodose ganglia are normal

small superior cervical ganglion ( J:17792 )

• superior cervical ganglia are smaller at early postnatal times

abnormal sensory neuron innervation pattern ( J:17792 )

• absence of primary sensory afferents in the dorsal horn of spinal cord

abnormal skin sensory neuron innervation pattern ( J:17792 )

• absence of primary sensory afferents in the dermis and epidermis

dorsal root ganglion hypoplasia ( J:17792 )

• dorsal root ganglia at P3 contain fewer neuronal profiles; neuronal cell counts from the fourth and fifth lumbar (L4 and L5) ganglia show a 70% reduction

• lumbar or cervical dorsal root ganglia show a complete absence of small cells in the ganglia but no evidence of cell loss in the large range

integument

abnormal hair growth ( J:17792 )

• delayed hair growth

abnormal skin sensory neuron innervation pattern ( J:17792 )

• absence of primary sensory afferents in the dermis and epidermis