Phenotypes Associated with This Genotype

Genotype
MGI:2171462

• Allelic Composition: Nrg1^tm1Gne/Nrg1^tm1Gne
• Genetic Background: either: (involves: 129S2/SvPas * BALB/c) or (involves: 129S2/SvPas * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:45302 )

• embryos were present up to E10.5

cardiovascular system

absent trabeculae carneae ( J:45302 )

enlarged heart ( J:45302 )

thin ventricular wall ( J:45302 )

poor circulation ( J:45302 )

irregular heartbeat ( J:45302 )

muscle

absent trabeculae carneae ( J:45302 )

nervous system

abnormal cranial ganglia morphology ( J:45302 )

• abnormal postition of the vestibulocochlear and geniculate ganglia

abnormal petrosal ganglion morphology ( J:45302 )

• disorganized

small nodose ganglion ( J:45302 )

abnormal hypoglossal nerve morphology ( J:45302 )

• posterior branches were rudimentary and failed to coalesce with the C1 and vagus nerves

abnormal trigeminal nerve morphology ( J:45302 )

• the ophthalmic division was unfasciculated

absent mandibular nerve ( J:45302 )

abnormal dorsal root ganglion morphology ( J:45302 )

• moderate cell death apparent

abnormal ventral spinal root morphology ( J:45302 )

• the normal constriction of the ventral root was absent

• a delay in the development of projections from the posterior ganglia was observed

• ventral root projections are defasciculated

growth/size/body

enlarged heart ( J:45302 )