Phenotypes Associated with This Genotype

Genotype
MGI:2171403

• Allelic Composition: En1^tm2Alj/En1^tm2Alj; En2^tm2Alj/En2^tm2Alj
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

absent rhombomere 1 ( J:66592 )

• most or all of r1 deleted by E9.5

decreased rhombomere 1 size ( J:66592 )

• most or all of r1 deleted by E9.5

abnormal midbrain-hindbrain boundary development ( J:66592 )

• development normal through early somite stage but abnormal by 10-12 somite stage

absent midbrain-hindbrain boundary ( J:66592 )

• general deletion of the mesencephalon/anterior metencephalon region at E9.5

absent inferior colliculus ( J:134516 )

• absent at E18.5

absent superior colliculus ( J:134516 )

• absent at E18.5

absent colliculi ( J:134516 )

absent tectum ( J:134516 )

absent midbrain ( J:66592 )

• mostly, if not entirely, deleted at E9.5

small cerebellum ( J:134516 )

• reduced in overall size by one-third at E18.5

embryo

absent rhombomere 1 ( J:66592 )

• most or all of r1 deleted by E9.5

decreased rhombomere 1 size ( J:66592 )

• most or all of r1 deleted by E9.5