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Phenotypes Associated with This Genotype
Genotype
MGI:2170906
Allelic
Composition		 Psen1tm1Shn/Psen1tm1Shn
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Shn mutation (2 available); any Psen1 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal apoptosis ( J:90392 )
• at E10 the total number of apoptotic cells and relative percentage of apoptotic cells to progenitor cells in the forebrain-midbrain junction is reduced about 50% compared to littermate controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory