Phenotypes Associated with This Genotype

Genotype
MGI:2170585

• Allelic Composition: Hoxa1^tm2Mrc/Hoxa1^tm2Mrc; Hoxa2^tm1Mrc/Hoxa2^tm1Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:58093 )

• die shortly after birth

hearing/vestibular/ear

abnormal middle ear ossicle morphology ( J:58093 )

• severe patterning defects in the middle ear and associated skeleton

small middle ear ossicles ( J:58093 )

• reduced size of middle ear elements

absent outer ear ( J:58093 )

• pinna of ear almost entirely absent

skeleton

abnormal middle ear ossicle morphology ( J:58093 )

• severe patterning defects in the middle ear and associated skeleton

small middle ear ossicles ( J:58093 )

• reduced size of middle ear elements

nervous system

abnormal hindbrain morphology ( J:58093 )

• extensive hindbrain defects affecting breathing

craniofacial

abnormal middle ear ossicle morphology ( J:58093 )

• severe patterning defects in the middle ear and associated skeleton

small middle ear ossicles ( J:58093 )

• reduced size of middle ear elements

absent outer ear ( J:58093 )

• pinna of ear almost entirely absent

growth/size/body

absent outer ear ( J:58093 )

• pinna of ear almost entirely absent