Phenotypes Associated with This Genotype

Genotype
MGI:2170514

• Allelic Composition: Myf5^tm1Pas/Myf5^tm1Pas
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

absent extraocular muscles ( J:150130 )

• at birth, mice completely lack extraocular muscles or only have residual myofibers unlike in wild-type mice

abnormal eye muscle development ( J:150130 )

• by E11.5, the extraocular muscle anlage fails to pattern and begins to atrophy unlike in wild-type mice

• extraocular muscle anlagen exhibits a 5- to 6-fold increase in apoptotic cells compared to in wild-type mice

embryo

delayed somite formation ( J:150130 )

• at E11.5, somatic muscle progenitor cells exhibit a temporary pause in development but do not apoptose

• however, somite fate is rescued thereafter by Myod1 expression

vision/eye

absent extraocular muscles ( J:150130 )

• at birth, mice completely lack extraocular muscles or only have residual myofibers unlike in wild-type mice

abnormal eye muscle development ( J:150130 )

• by E11.5, the extraocular muscle anlage fails to pattern and begins to atrophy unlike in wild-type mice

• extraocular muscle anlagen exhibits a 5- to 6-fold increase in apoptotic cells compared to in wild-type mice