Phenotypes Associated with This Genotype

Genotype
MGI:2169746

• Allelic Composition: Mafb^kr/Mafb^kr
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

head tossing ( J:15032 )

hyperactivity ( J:15032 )

circling ( J:15032 )

hearing/vestibular/ear

abnormal otic vesicle development ( J:13001 , J:15032 )

• at E9 the otic vesicle is in an abnormal position, likely due to abnormal neural tube development (J:13001)

• an imperfect capsule forms around the vesicle (J:13001)

abnormal inner ear morphology ( J:13001 )

• the adult ear mainly comprises a large sac containing endolymphatic and perilymphatic spaces

abnormal bony labyrinth ( J:13001 )

inner ear cyst ( J:15032 )

• extracapsular cysts grow through gaps in the otic capsule become quite large and locate under the brain

abnormal otic capsule development ( J:13001 )

• the capsule is not continuous allowing extracapsular cysts to grow into the otic vesicle

abnormal cochlear sensory epithelium morphology ( J:13001 )

• only occasional areas of sensory epithelium are noted

abnormal membranous labyrinth morphology ( J:13001 )

reproductive system

reduced female fertility ( J:15032 )

♀

reduced male fertility ( J:15032 )

♂ • males are more likely to breed than females

embryo

abnormal neural tube morphology ( J:1490 , J:13001 )

• at E9.5 the neural tube posterior to the boundary between rhombomeres 3 and 4 appears unsegmented (J:1490)

• abnormal segmentation of the neural tube in the region of the rhombencephalon is seen in E8.75 embryos (J:13001)

abnormal rhombomere 4 morphology ( J:1490 , J:13001 )

• at E9.5 the region normally corresponding to rhombomere 4 is unusually thick-walled and contains many dying cells (J:1490)

• extensive cell degeneration occurs in the fourth rhombomere after E8 (J:13001)

abnormal rhombomere 5 morphology ( J:1490 )

• at E9.5 the region normally corresponding to rhombomere 5 is unusually thick-walled and contains many dying cells

nervous system

abnormal neural tube morphology ( J:1490 , J:13001 )

• at E9.5 the neural tube posterior to the boundary between rhombomeres 3 and 4 appears unsegmented (J:1490)

• abnormal segmentation of the neural tube in the region of the rhombencephalon is seen in E8.75 embryos (J:13001)

abnormal rhombomere 4 morphology ( J:1490 , J:13001 )

• at E9.5 the region normally corresponding to rhombomere 4 is unusually thick-walled and contains many dying cells (J:1490)

• extensive cell degeneration occurs in the fourth rhombomere after E8 (J:13001)

abnormal rhombomere 5 morphology ( J:1490 )

• at E9.5 the region normally corresponding to rhombomere 5 is unusually thick-walled and contains many dying cells

abnormal hindbrain development ( J:1490 )

craniofacial

abnormal bony labyrinth ( J:13001 )

growth/size/body

inner ear cyst ( J:15032 )

• extracapsular cysts grow through gaps in the otic capsule become quite large and locate under the brain

skeleton

abnormal bony labyrinth ( J:13001 )