Phenotypes Associated with This Genotype

Genotype
MGI:2169483

• Allelic Composition: Bmp4^tm1Blh/Bmp4^tm1Blh
• Genetic Background: involves: 129S2/SvPas * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:51570 )

• at E10.5

growth/size/body

embryonic growth retardation ( J:51570 , J:53311 )

• at E10.5, homozygotes have 20-27 somites, while littermates have greater than 35 (J:51570)

vision/eye

abnormal lens induction ( J:51570 )

• failure of lens placode induction

embryo

embryonic growth retardation ( J:51570 , J:53311 )

• at E10.5, homozygotes have 20-27 somites, while littermates have greater than 35 (J:51570)

absent allantois ( J:53311 )

• all embryos lacked an allantois

reproductive system

absent primordial germ cells ( J:53311 )

endocrine/exocrine glands

absent Rathke's pouch ( J:50517 )

• no sign of Rathke's pouch formation (either ectodermal thickening or invagination) is noted at E9.5-E9.75

nervous system

absent Rathke's pouch ( J:50517 )

• no sign of Rathke's pouch formation (either ectodermal thickening or invagination) is noted at E9.5-E9.75

cellular

absent primordial germ cells ( J:53311 )