Phenotypes Associated with This Genotype

Genotype
MGI:2168872

• Allelic Composition: Ctnnb1^tm1Max/Ctnnb1^tm1Max
• Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:29881 )

• no homozygous mutants born from crosses of heterozygotes

• development seemed normal through E7

• by E8.5 cell death could be observed in some areas

• resorption continuing at E9.5 when most organized structure disappeared

embryo

abnormal germ layer development ( J:29881 )

• the 3 germ layers fail to form

decreased embryo size ( J:29881 )

• by E7.5 homozygotes were about half normal length

abnormal embryonic epiblast morphology ( J:29881 )

• around E7.0 cells begin detaching from the embryonic ectoderm and disperse into the proamniotic cavity

abnormal extraembryonic tissue morphology ( J:29881 )

• extraembryonic cavities failed to form

absent allantois ( J:29881 )

• allantois failed to form

absent amniotic folds ( J:29881 )

growth/size/body

decreased embryo size ( J:29881 )

• by E7.5 homozygotes were about half normal length