Phenotypes Associated with This Genotype

Genotype
MGI:2168248

• Allelic Composition: Hgf^tm1Cbm/Hgf^tm1Cbm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:23170 )

• die between E13.5-E16.5

growth/size/body

decreased fetal weight ( J:23170 )

• a 17% reduction in body weight resulted in a reduced fetal size at E14.5; this size difference is not apparent at E12.5

cardiovascular system

dilated liver sinusoidal space ( J:23170 )

internal hemorrhage ( J:23170 )

• at E14.5; incompletely penetrant

irregular heartbeat ( J:23170 )

• at E14.5; incompletely penetrant

liver/biliary system

abnormal liver morphology ( J:23170 )

• loosened liver structure seen at E14.5

dilated liver sinusoidal space ( J:23170 )

abnormal hepatocyte morphology ( J:23170 )

• abnormal morphology and reduction in number

• no changes in growth or survival of remaining hepatocytes

dissociated hepatocytes ( J:23170 )

• dissociated parenchymal cells exhibit signs of apoptosis

small liver ( J:23170 )

• 40% average reduction at E12.5 and 55% average reduction at E14.5

liver hypoplasia ( J:23170 )

• severe loss of cellularity noted, with the ventral side of the liver most affected

hematopoietic system

decreased erythrocyte cell number ( J:23170 )

• reduced erythrocyte counts and reduced embryonal blood frequently observed, probably due to decreased liver size

embryo

abnormal placenta morphology ( J:23170 )

decreased trophoblast giant cell number ( J:23170 )

• the number of trophoblast cells is severely reduced

disorganized placental labyrinth ( J:23170 )

• the entire labyrinth layer appears disorganized