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Phenotypes Associated with This Genotype
Genotype
MGI:2168183
Allelic
Composition
Adatm1Mw/Adatm1Mw
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adatm1Mw mutation (3 available); any Ada mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• mice exhibit increased corpus cavernosal smooth muscle relaxation in response to nerve stimulation
• mice exhibit erections lasting up to 72 hours that is associated with increased camp and cGMP production
• however, treatment with PEG-ADA corrects the observed priapism
• mice exhibit penile vascular damage, including marked intimal thickening with smooth muscle hypertrophy and endothelial swelling, and fibrosis subsequent to priapism

Mouse Models of Human Disease
OMIM ID Ref(s)
Priapism, Familial Idiopathic 176620 J:135978


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory