Mouse Genome Informatics
hm
    Adatm1Mw/Adatm1Mw
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• mice exhibit increased corpus cavernosal smooth muscle relaxation in response to nerve stimulation
• mice exhibit erections lasting up to 72 hours that is associated with increased camp and cGMP production
• however, treatment with PEG-ADA corrects the observed priapism
• mice exhibit penile vascular damage, including marked intimal thickening with smooth muscle hypertrophy and endothelial swelling, and fibrosis subsequent to priapism

Mouse Models of Human Disease
OMIM IDRef(s)
Priapism, Familial Idiopathic 176620 J:135978