Analysis Tools
reproductive system
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• mice exhibit increased corpus cavernosal smooth muscle relaxation in response to nerve stimulation
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• mice exhibit erections lasting up to 72 hours that is associated with increased camp and cGMP production
• however, treatment with PEG-ADA corrects the observed priapism
• mice exhibit penile vascular damage, including marked intimal thickening with smooth muscle hypertrophy and endothelial swelling, and fibrosis subsequent to priapism
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