Mouse Genome Informatics
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
• mice exhibit increased corpus cavernosal smooth muscle relaxation in response to nerve stimulation (J:135978)
• mice exhibit erections lasting up to 72 hours that is associated with increased camp and cGMP production (J:135978)
• however, treatment with PEG-ADA corrects the observed priapism (J:135978)
• mice exhibit penile vascular damage, including marked intimal thickening with smooth muscle hypertrophy and endothelial swelling, and fibrosis subsequent to priapism (J:135978)

Mouse Models of Human Disease
Priapism, Familial Idiopathic 176620 J:135978