All Phenotypes Prodh2<em1Jkni> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prodh2^em1Jkni/Prodh2^em1Jkni	involves: C57BL/6J	MGI:6472958
cx2	Grhpr^{Gt(OST383093)Lex}/Grhpr^{Gt(OST383093)Lex} Prodh2^em1Jkni/Prodh2^em1Jkni	involves: 129S5/SvEvBrd * C57BL/6J	MGI:6472962
cx3	Agxt^tm1Ull/Agxt^tm1Ull Prodh2^em1Jkni/Prodh2^em1Jkni	involves: 129X1/SvJ * C57BL/6J	MGI:6472960

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating hydroxyproline level ( J:283585 )

• plasma trans-4-hydroxy-L-proline (hydroxyproline) levels are elevated

abnormal urine homeostasis ( J:283585 )

• males, but not females, fed a low-oxalate, no-hydroxyproline diet exhibit 20% lower urinary glycolate levels than wild-type mice

hydroxyprolinuria ( J:283585 )

• urinary trans-4-hydroxy-L-proline excretion levels are elevated

abnormal urine organic anion level ( J:283585 )

• males, but not females, fed a low-oxalate, no-hydroxyproline diet exhibit 18% lower urinary oxalate levels than wild-type mice

decreased physiological sensitivity to xenobiotic ( J:283585 )

• mice fed a 1% hydroxyproline diet excrete lower levels of urinary oxalate and glycolate compared to wild-type mice

• mice fed a 1% hydroxyproline diet exhibit kidney oxalate levels approximately 4-fold lower than in wild-type mice

renal/urinary system

renal/urinary system phenotype ( J:283585 )

N	• mice show normal kidney histology and normal urinary volume and creatinine excretions

abnormal urine homeostasis ( J:283585 )

• males, but not females, fed a low-oxalate, no-hydroxyproline diet exhibit 20% lower urinary glycolate levels than wild-type mice

hydroxyprolinuria ( J:283585 )

• urinary trans-4-hydroxy-L-proline excretion levels are elevated

abnormal urine organic anion level ( J:283585 )

• males, but not females, fed a low-oxalate, no-hydroxyproline diet exhibit 18% lower urinary oxalate levels than wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:283585 )

N	• mice develop normally and exhibit similar behavior to wild-type mice

liver/biliary system

liver/biliary system phenotype ( J:283585 )

N	• mice exhibit normal liver histology

Allelic Composition	Grhpr^{Gt(OST383093)Lex}/Grhpr^{Gt(OST383093)Lex} Prodh2^em1Jkni/Prodh2^em1Jkni
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhpr^{Gt(OST383093)Lex} mutation (1 available); any Grhpr mutation (19 available)
Prodh2^em1Jkni mutation (0 available); any Prodh2 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperoxaluria ( J:283585 )

• mice show increased urinary oxalate excretion compared to wild-type mice but reduced excretion compared to single Prodh2 homozygotes

decreased physiological sensitivity to xenobiotic ( J:283585 )

• mice fed a 1% hydroxyproline diet exhibit kidney oxalate levels approximately 1300-fold lower than in wild-type mice, indicating prevention of calcium-oxalate crystal deposition in the kidney

renal/urinary system

hyperoxaluria ( J:283585 )

• mice show increased urinary oxalate excretion compared to wild-type mice but reduced excretion compared to single Prodh2 homozygotes

Allelic Composition	Agxt^tm1Ull/Agxt^tm1Ull Prodh2^em1Jkni/Prodh2^em1Jkni
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agxt^tm1Ull mutation (0 available); any Agxt mutation (16 available)
Prodh2^em1Jkni mutation (0 available); any Prodh2 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal urine homeostasis ( J:283585 )

• mice show lowered urinary glycolate levels compared to single Agxt homozygotes

hyperoxaluria ( J:283585 )

• mice show increased urinary oxalate excretion compared to wild-type mice but reduced excretion compared to single Agxt homozygotes

renal/urinary system

abnormal urine homeostasis ( J:283585 )

• mice show lowered urinary glycolate levels compared to single Agxt homozygotes

hyperoxaluria ( J:283585 )

• mice show increased urinary oxalate excretion compared to wild-type mice but reduced excretion compared to single Agxt homozygotes

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