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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gpr27tm1Tac
targeted mutation 1, Taconic
MGI:6423080
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gpr27tm1Tac/Gpr27tm1Tac B6.129S-Gpr27tm1Tac MGI:6456975


Genotype
MGI:6456975
hm1
Allelic
Composition
Gpr27tm1Tac/Gpr27tm1Tac
Genetic
Background
B6.129S-Gpr27tm1Tac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr27tm1Tac mutation (0 available); any Gpr27 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at 12 weeks of age, chow-fed mice are 10% lighter than wild-type controls
• however, no significant difference in body weight is observed after high-fat feeding

homeostasis/metabolism
• at 12 weeks of age, chow-fed mice show a significant reduction in plasma insulin measured 15 minutes after glucose challenge
• however, isolated islets show no defect in fractional insulin secretion in response to glucose or potassium chloride stimulation
• on a chow diet, plasma insulin levels are reduced but insulin sensitivity is normal
• plasma insulin levels are also decreased after high-fat feeding
• on a chow diet, mice show slightly impaired glucose tolerance at 12 weeks of age
• mildly impaired glucose tolerance is also observed after high-fat feeding

endocrine/exocrine glands
• Ins1/2 and Pdx1 mRNA are reduced by 30% in pancreatic islets
• however, no reduction in islet insulin content or beta cell mass is observed and the distribution of islet sizes is normal
• at 12 weeks of age, chow-fed mice show a significant reduction in plasma insulin measured 15 minutes after glucose challenge
• however, isolated islets show no defect in fractional insulin secretion in response to glucose or potassium chloride stimulation





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory