Phenotypes associated with this allele

• Allele Symbol: Cdnf^tm1.1Uhb
• Allele Name: targeted mutation 1.1, University of Helsinki, Biocenter
• Allele ID: MGI:6394118
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdnf^tm1.1Uhb/Cdnf^tm1.1Uhb	either: B6JRcc.129P2(Cg)-Cdnf^tm1.1Uhb or (involves: 129P2/OlaHsd * C57BL/6JRcc * ICR)	MGI:6400267

Genotype
MGI:6400267

hm1

• Allelic Composition: Cdnf^tm1.1Uhb/Cdnf^tm1.1Uhb
• Genetic Background: either: B6JRcc.129P2(Cg)-Cdnf^tm1.1Uhb or (involves: 129P2/OlaHsd * C57BL/6JRcc * ICR)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:285339 )

N • mice exhibit normal general architecture of midbrain dopaminergic neurons

abnormal enteric neuron morphology ( J:285339 )

• aged mice exhibit greater enteric neuron loss than wild-type mice

• reduced packing density of submucosal neurons

• however, mice exhibit normal enteric neuron apoptosis rates, packing density of myenteric neurons and density of glia

abnormal submucous nerve plexus morphology ( J:285339 )

• hypoplasia in 1.5 month mice and persisting through adulthood

neurodegeneration ( J:285339 )

• of enteric neurons in the submucosal plexus of the duodenum, ileum, and colon

abnormal neuron physiology ( J:285339 )

• reduced dopamine re-uptake by dopamine transporter at 6 months of age

• however, dopamine release is normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:285339 )

N • mice exhibit normal blood glucose levels

enhanced autophagy ( J:285339 )

• in submucosal enteric neurons

• however, autophagy is normal in the myenteric plexus

abnormal dopamine level ( J:285339 )

• reduced dopamine re-uptake by dopamine transporter at 6 months of age

• however, dopamine release is normal

increased nervous system dopamine level ( J:285339 )

• amphetamine-induced, especially in 9 to 12 month old mice

behavior/neurological

enhanced behavioral response to amphetamine ( J:285339 )

• enhanced amphetamine-induced hyperlocomotion in 7 to 9 month old mice

cellular

enhanced autophagy ( J:285339 )

• in submucosal enteric neurons

• however, autophagy is normal in the myenteric plexus

growth/size/body

growth/size/body region phenotype ( J:285339 )

N • exhibit normal growth and weight