Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Knl1tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Knl1 mutation
(102 available)
Tg(GFAP-cre)25Mes mutation
(2 available)
Trp53tm1Brn mutation
(18 available);
any
Trp53 mutation
(232 available)
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mortality/aging
nervous system
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N |
• neuron loss is rescued by conditional knock-out of Trp53
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• partially rescued by conditional knock-out of Trp53
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cellular
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• partial rescue of apoptosis and DNA damage by conditional knock-out of Trp53
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growth/size/body
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• partially rescued by conditional knock-out of Trp53
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation
(2 available);
any
Emx1 mutation
(34 available)
Knl1tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Knl1 mutation
(102 available)
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nervous system
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• in deep and upper layers
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growth/size/body
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• more severe than in mice with the conditional activated by Tg(GFAP-cre)25Mes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Knl1tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Knl1 mutation
(102 available)
Tg(GFAP-cre)25Mes mutation
(2 available)
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mortality/aging
nervous system
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• neural progenitor cells prematurely exhibit the cell cycle and become migratory
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• mis-segregated chromosomes with DNA bridges located at the cleavage furrow
• however, karyotypes are normal
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• at E15.5 and E16.5 with some precursor cells located outside the ventricular zone and subventricular zone
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• POU3F2-expressing L2-5 neurons
• CUX1-expressing L2-4 neurons
• due to increased apoptosis
• however, deep layer neuron numbers are normal
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cellular
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• mis-segregated chromosomes with DNA bridges located at the cleavage furrow
• however, karyotypes are normal
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• in the cortex at E15.5, abundant in the germinal zones and intermediate zone
• marginally by E17.5
• associated with increased DNA damage determined by gammaH2AX staining
• however, apoptotic cells are largely absent from the cortical plate
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• neural progenitor cells prematurely exhibit the cell cycle and become migratory
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growth/size/body
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• less severe than in mice with the conditional activated by Emx1tm1(cre)Krj
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homeostasis/metabolism
immune system
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• mis-segregated chromosomes with DNA bridges located at the cleavage furrow
• however, karyotypes are normal
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hematopoietic system
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• mis-segregated chromosomes with DNA bridges located at the cleavage furrow
• however, karyotypes are normal
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Analysis Tools