Phenotypes associated with this allele

• Allele Symbol: Tg(Prnp-HTT*82Q)61Gschi
• Allele Name: transgene insertion 61, Gabriele Schilling
• Allele ID: MGI:6294292
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Prnp-HTT*82Q)61Gschi/0	involves: C3H/HeJ * C57BL/6J	MGI:6294294

Genotype
MGI:6294294

tg1

• Allelic Composition: Tg(Prnp-HTT*82Q)61Gschi/0
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:91795 )

• mice die between 11 and 16 months of age

growth/size/body

weight loss ( J:91795 )

• mice exhibit reduced weight towards the end of their life

behavior/neurological

poor grooming ( J:91795 )

• mice exhibit poor grooming towards the end of life

limb grasping ( J:91795 )

• mice exhibit hind-limb clasping when suspended by the tail towards the end of life

hunched posture ( J:91795 )

• mice exhibit hunched posture towards the end of life

nervous system

neuronal intranuclear inclusions ( J:91795 )

• mice exhibit widespread nuclear inclusions of HTT in most neurons of the CNS, however no cytoplasmic inclusions are detected

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:91795