All Phenotypes Cngb3<cpfl10> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cngb3^cpfl10
cone photoreceptor function loss 10
MGI:6274478

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cngb3^cpfl10/Cngb3^cpfl10	involves: 129S6/SvEvTac * C57BL/6J	MGI:6275192

Allelic Composition	Cngb3^cpfl10/Cngb3^cpfl10
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cngb3^cpfl10 mutation (0 available); any Cngb3 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

decreased retina cone cell number ( J:269211 )

• progressive and more severe than expected with normal aging

• not as severe as in mice homozygous for Cngb3^tm1Dgen

retina cone cell degeneration ( J:269211 )

abnormal cone electrophysiology ( J:269211 )

• completely absent or substantially reduced light-adapted cone responses

• however, dark-adapted rod response is normal

nervous system

decreased retina cone cell number ( J:269211 )

• progressive and more severe than expected with normal aging

• not as severe as in mice homozygous for Cngb3^tm1Dgen

retina cone cell degeneration ( J:269211 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
achromatopsia 3		DOID:0110008	OMIM:262300	J:269211

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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