Phenotypes associated with this allele

• Allele Symbol: Cdk10^tm1.2Kald
• Allele Name: targeted mutation 1.2, Philipp Kaldis
• Allele ID: MGI:6201331
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk10^tm1.2Kald/Cdk10^tm1.2Kald	involves: 129 * C57BL/6 * FVB/N	MGI:6201401

Genotype
MGI:6201401

hm1

• Allelic Composition: Cdk10^tm1.2Kald/Cdk10^tm1.2Kald
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:262333 )

• despite being present at E17.5, fewer than expected mice are born and very few survivors the first day of life

renal/urinary system

abnormal kidney morphology ( J:262333 )

• severe tubulonephrosis

abnormal renal tubule morphology ( J:262333 )

• affected tubules exhibit severely attenuated mineralized epithelium with lumens containing mineralized casts

renal tubular necrosis ( J:262333 )

• in 30% to 50% of renal tubules

abnormal renal tubule epithelium morphology ( J:262333 )

• affected tubules exhibit severely attenuated mineralized epithelium with lumens containing mineralized casts

• some tubules are lined with swollen and vacuolated epithelium with occasional nuclear pyknosis

renal tubule atrophy ( J:262333 )

• in 30% to 50% of renal tubules

respiratory system

primary atelectasis ( J:262333 )

• severe and likely cause of death

• affected mice have few inflated alveoli containing squamous debris and activated foamy macrophages in the lumen

thick pulmonary interalveolar septum ( J:262333 )

• collapsed in mice that do not survive with collapsed alveolar walls and few lymphocytes and macrophages

abnormal bronchiole morphology ( J:262333 )

• partially filled with eosinophilic fluid and squamous debris

skeleton

mandible hypoplasia ( J:262333 )

short femur ( J:262333 )

• left femur

split cervical atlas ( J:262333 )

• bifidity at C1 and C2

absent odontoid process ( J:262333 )

split cervical axis ( J:262333 )

• bifidity at C1 and C2

decreased bone mineralization ( J:262333 )

• reduced volume of mineralized matrix from the head, femur, tibia, and fibula

cardiovascular system

abnormal heart morphology ( J:262333 )

growth/size/body

postnatal growth retardation ( J:262333 )

• severe at P0

fetal growth retardation ( J:262333 )

• severe at E17.5

craniofacial

mandible hypoplasia ( J:262333 )

immune system

abnormal spleen morphology ( J:262333 )

hematopoietic system

abnormal spleen morphology ( J:262333 )

limbs/digits/tail

short femur ( J:262333 )

• left femur

liver/biliary system

abnormal liver morphology ( J:262333 )

muscle

abnormal muscle morphology ( J:262333 )

cellular

renal tubular necrosis ( J:262333 )

• in 30% to 50% of renal tubules