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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Srcinl
incisor-less
MGI:5911893
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Srcinl/Srcinl involves: 129 MGI:5911896


Genotype
MGI:5911896
hm1
Allelic
Composition
Srcinl/Srcinl
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srcinl mutation (0 available); any Src mutation (121 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• viable for at least 1 year when fed a special mashed food diet

craniofacial
• shortened both anteriorly and posteriorly
• variable number of molars
• typically missing one or two of the molars either in the upper or lower jaw
• significant reduction in length of almost all measures of the skull

behavior/neurological
• show shorter freezing time in a cued fear test compared to wild-type controls
• however, freezing time is similar in a context test and shock pain thresholds are similar to controls
• spend less time walking on a rotating rod on days 3 and 4 but not on days 1 and 2, suggesting a defect in learning
• do not show a preference for the target location in probe trials in a Morris water maze
• however, escape performance is similar to controls in the visible and the hidden platform tasks
• spend less time in the center of an open field
• however, no differences in time spent in the open arm are detected in an elevated plus maze
• impaired ability to selectively react to a spatial and novelty change in the environment showing no preference for a displaced or novel object
• at 115 dB, but not at 70-105 dB
• take longer to cross a balance beam and have an increased number of foot slips
• for both forelimb alone and the forelimb and hindlimb combined
• show increased distance traveled in an open field assay
• when given a choice between a social vs nonsocial object, homozygotes spend more time with the social object (mouse) compared to wild-type controls
• in a direct social investigation assay homozygotes spend more time in active social approaches compared to wild-type controls
• in a social dominance assay, homozygotes show dominance over wild-type mice in approximately 70% of matches
• spend more time with familiar vs non-familiar mouse unlike wild-type controls
• unable to distinguish between a familiar and non-familiar mouse
• in a female-female social reunion assay, homozygous females emit more ultrasonic vocalizations in both the first and second minute compared to wild-type controls

growth/size/body
• variable number of molars
• typically missing one or two of the molars either in the upper or lower jaw
• significant reduction in length of almost all measures of the skull

skeleton
• shortened both anteriorly and posteriorly
• variable number of molars
• typically missing one or two of the molars either in the upper or lower jaw

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Williams-Beuren syndrome DOID:1928 OMIM:194050
J:229610





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory